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Breakthrough or Band-Aid? New Drug for Primary Aldosteronism Sparks Debate
TAMPA, Fla., Oct. 16, 2025 /PRNewswire/ — A new drug aimed at treating primary aldosteronism—the most common but often overlooked cause of high blood pressure—is making waves in the medical community. But…
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Will Power Eager To Rediscover Sports Car Racing on Familiar Turf
Two-plus decades have passed since Will Power last raced a production-based sports car in Australia’s Bathurst 24 Hour in 2003 in a Porsche 996.
The two-time NTT INDYCAR SERIES champion said he has looked for the right opportunity…
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Stock market today: Live updates
Traders work on the floor of the New York Stock Exchange (NYSE) on October 13, 2025, in New York City.
Spencer Platt | Getty Images
Stocks fell Thursday, giving up earlier gains, led by declines in bank stocks on worries about bad loans. Traders also juggled persistent trade tensions and an ongoing U.S. government shutdown.
The Dow Jones Industrial Average lost 411 points, or 0.9%, after gaining 170 points at one point. The S&P 500 traded nearly 1% lower, giving up a 0.6% gain at the highs of the session. The Nasdaq Composite fell 0.9%.
Regional banks Zions and Western Alliance fell to their lows of the day as indexes rolled over. Zions plunged 12% after taking a sizable charge because of bad loans to a couple borrowers. Western Alliance dropped 10% after alleging a borrower had committed fraud.
“The market is just really skittish about credit-related losses,” Jed Ellerbroek, portfolio manager at Argent Capital Management, told CNBC. “The market is not very happy about [the regional banks’ comments], so most small-cap financials, banks are down today.”
The banking industry has been on edge lately following the bankruptcies of two auto industry-related companies that have raised concerns about loose lending practices, especially in the opaque private credit market.
“When you see one cockroach, there are probably more,” JPMorgan CEO Jamie Dimon said on the bank’s earnings conference call earlier this week, related to the collapse of First Brands and Tricolor Holdings. Jefferies, which has some exposure to First Brands, shed 10% on Thursday, bringing its losses for the month to 25%.
Zions, 1 day
The decline in stocks coincided with a jump in the Cboe Volatility Index and moves lower in bond yields and the U.S. dollar. The Vix spiked to its highest since May, while the 10-year Treasury yield fell and broke below 4%. The U.S. dollar index lost 0.4% and hit its lows of the session midday.
Trade tensions between China and the U.S. recently increased, adding to volatility on Wall Street.
President Donald Trump last week threatened to place an additional 100% tariff on any goods coming from China in response to the country’s new export controls on rare earth minerals. The trade tone softened over subsequent days, but tensions increased again Tuesday, when Trump on threatened China with a cooking oil trade ban.
“The Trump administration desires to influence and control a lot more things than past administrations have … so they’re constantly jolting the market in unexpected ways,” Ellerbroek said. “That’s going to continue, and investors just have to kind of accept that as a new fact of life and be on their toes.”
Investors are also keeping a watchful eye as the U.S. government shutdown continues for a third week. The stoppage has led to an indefinite shutdown of crucial economic data releases from federal agencies.
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Official data dramatically underestimates hedge funds’ involvement in the Treasury market, Fed paper finds
By Vivien Lou Chen
Treasury Department data does not reflect how much hedge funds domiciled in the Cayman Islands are dominating the so-called basis trade, according to a team at the Federal Reserve.
Data from the U.S. Treasury Department is failing to capture Cayman Island hedge-fund exposures to Treasury securities.
Key Treasury Department data is massively underreporting the amount of U.S. government debt held by hedge funds registered and incorporated in the Cayman Islands, and is failing to reflect their heavy reliance on a controversial leveraged trade that has repeatedly alarmed regulators.
In a note released on Wednesday, a team at the Federal Reserve found that U.S. Treasury International Capital data appears to be “severely” undercounting the amount of Treasurys held by those hedge funds, to the tune of about $1.4 trillion as of the end of the 2024. In addition, the Fed team concluded that TIC data is not capturing just how much Cayman-domiciled hedge funds are dominating positions in the so-called basis trade.
Since at least 2018, U.S. regulators have periodically expressed alarm over the possibility that the basis trade could trigger wider financial instability during market downturns. The Treasury Department’s press office did not immediately respond to a request for comment on Thursday. The U.S. government has been in a partial shutdown since Oct. 1.
The basis trade uses leverage to arbitrage the price differences between Treasury futures and cash Treasurys. It involves simultaneously buying a Treasury cash position and selling a Treasury futures position, and financing the trade by borrowing in the repo market to provide leverage. The unwinding of the basis trade was seen as a likely contributor to Treasury-market instability in March 2020, and the risk of a possible repeat following hedge funds’ increased reliance on leverage drew scrutiny from the Fed’s board of governors and the Treasury in 2023.Read: Hedge funds’ use of leveraged Treasury trades needs ‘diligent monitoring,’ Fed paper says
TIC data is the main source of U.S. data on cross-border securities and banking. It is used by policymakers, investors and researchers to understand the catalysts and impacts of cross-border flows and asset allocations among various countries and investor types.
The severe underreporting of Cayman-domiciled funds’ Treasurys holdings presents “a major impediment for researchers, policymakers, and other data users seeking to analyze cross-border flows and their effects on the U.S. economy and financial markets,” according to the note written by Daniel Barth, principal economist for the Federal Reserve Board; Daniel Beltran, a deputy associate director; Maria Perozek, chief of the board’s Flow of Funds section; and others. The authors estimate that holdings of Treasury securities of Cayman-domiciled hedge funds stood at $1.85 trillion by the end of 2024, having climbed by $1 trillion since 2022.
“Our findings suggest that Cayman Islands hedge funds are, increasingly, the marginal foreign buyers of U.S. Treasury notes and bonds,” the authors said. After factoring in an estimated underreporting of roughly $1.4 trillion, they wrote, the Cayman Islands “is in fact the largest foreign holder of U.S. Treasury securities – holding significantly more than China, Japan, and the United Kingdom,” which currently rank as the three largest holders.
Hedge funds domiciled in the Cayman Islands held an estimated $1.85 trillion in Treasurys at the end of 2024, according to a note from the Federal Reserve.
Meanwhile, the gap between what’s being reported in the Treasury Department’s TIC data versus what’s reported to the Securities and Exchange Commission has widened to almost $1.4 trillion as of the end of last year. “TIC data on Cayman Islands holdings of Treasuries do not appear to be picking up the Treasury transactions associated with the basis trade activity” that can be seen on the hedge funds’ filings to the SEC, according to the Fed note.
While this roughly $1.4 trillion gap is not solely attributable to the basis trade, “the puzzling disconnect between the TIC and [SEC’s] Form PF data on Cayman Islands’ holdings of U.S. Treasuries is under active investigation,” Barth and the other authors wrote.
The amount of Treasurys held by hedge funds domiciled in the Cayman Islands is far greater than what is being reported in the Treasury Department’s TIC data, according to a note from the Federal Reserve.
On Thursday, U.S. government debt rallied, sending Treasury yields lower across the board, as investors digested a mix of worries about trade tensions between the U.S. and China, the partial government shutdown, and bad loans in the bank industry. Separately, U.S. stocks DJIA SPX COMP were falling in afternoon trading.
-Vivien Lou Chen
This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.
(END) Dow Jones Newswires
10-16-25 1424ET
Copyright (c) 2025 Dow Jones & Company, Inc.
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Al Pacino on co-star and ex-girlfriend Diane Keaton: ‘She lived without limits’ | Diane Keaton
Al Pacino has paid tribute to the his co-star and ex-romantic partner Diane Keaton who died last week.
The 85-year-old actor had been filming in Paris and reportedly needed some time to put together his thoughts and feelings on Keaton, who died of…
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Immunotherapy EO2463 Receives FDA Fast Track for Follicular Lymphoma | Targeted Oncology
The FDA has granted fast track designation to the novel immunotherapy EO2463 for the treatment of follicular lymphoma, backed by positive interim data from the ongoing phase 2 SIDNEY trial (NCT04669171).1
Under this fast track designation, Enterome, the sponsor, will be eligible for more frequent opportunities for interaction with the FDA, rolling review, and potential eligibility for priority review if criteria are met, in hopes of bringing the therapy to patients sooner.2
“The FDA’s decision is an important validation of the unique potential of Enterome’s OncoMimics™ program,” said Pierre Belichard, chief executive officer of Enterome, in a news release.1 “It will expedite the clinical development and the regulatory pathways for EO2463, which is ready to enter registrational testing as early as next year after this fast track designation and a recent positive type C meeting with the FDA.”
What Is the Unmet Need in Follicular Lymphoma?
Follicular lymphoma, an indolent subtype of non-Hodgkin lymphoma (NHL), is characterized by slow disease progression and few symptoms yet shortened life expectancy, in part due to lack of a cure.
The condition exhibits potential for spontaneous remissions, suggesting the role of the immune system in such cases.3 While this invites an opportunity for treatment through immunotherapies, the disease’s high frequency of relapse necessitates immunotherapies that produce deep, durable antitumor responses.
How Is EO2463 Addressing This Need?
EO2463 is a novel therapeutic vaccine candidate that utilizes Enterome’s proprietary OncoMimics™ platform. Drugs that use this platform are designed using AI and machine learning to mimic tumor-associated antigens or lineage markers, drawing from a database of 23 million commensal bacteria genes to drive strong and lasting immune responses.1 Specifically, EO2463 is a combination of 4 synthetic OncoMimics™ microbial-derived peptides that correspond to 4 B cell markers: CD20, CD22, CD37, and CD268, as well as the CD4 helper-epitope UCP2.3
The nonrandomized, open-label phase 1/2 SIDNEY trial is evaluating the safety and preliminary efficacy of EO2463 monotherapy and in combination with lenalidomide (Revlimid) and/or rituximab (Rituxan) in patients with indolent NHL, including those with follicular lymphoma and marginal zone B-cell lymphoma, with an estimated enrollment of 60 patients across 4 cohorts.4
The primary outcome of phase 2 is objective response rate (ORR). In an early data report, the majority of patients remained on study treatment, with an observed ORR of 46% in the first 13 patients.5 Moreover, data presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting show that EO2463 monotherapy was well tolerated by patients, with no severe adverse events.3
This clinical activity primes EO2463 as a promising alternative treatment option for this patient population who may otherwise go untreated in a standard “watch-and-wait” approach.
REFERENCES:
1. Enterome receives FDA Fast Track designation in follicular lymphoma for lead OncoMimics™ immunotherapy EO2463. News release. BioSpace. October 16, 2025. Accessed October 16, 2025.
https://tinyurl.com/4ahshump 2. Fast Track. US Food & Drug Administration. Updated August 13, 2024. Accessed October 16, 2025.
https://tinyurl.com/ms2695jn 3. Villasboas JC, Wallace D, Smith SD, et al. Phase 1/2 of EO2463 immunotherapy as monotherapy and in combination with lenalidomide and/or rituximab in indolent NHL (EONHL1-20/SIDNEY). J Clin Oncol. 2024;42(16_suppl):7058-7058. doi:https://doi.org/10.1200/jco.2024.42.16_suppl.7058
4. A Novel Vaccine (EO2463) as Monotherapy and in Combination, for Treatment of Patients With Indolent Non-Hodgkin Lymphoma (SIDNEY). ClinicalTrials.gov. Updated December 13, 2024. Accessed October 16, 2025.
https://www.clinicaltrials.gov/study/NCT04669171 5. Enterome’s Immunotherapy EO2463 Shows Early Clinical Response in Newly Diagnosed Follicular Lymphoma Suggesting a Potential Alternative to ‘Watchful Waiting’. News release. Enterome. December 10, 2024. Accessed October 16, 2025.
https://www.enterome.com/news-events/enteromes-immunotherapy-eo2463-shows-early-clinical-response-in-newly-diagnosed-follicular-lymphoma-suggesting-a-potential-alternative-to-watchful-waiting/ Continue Reading
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Eye scan shows nerve damage, inflammation in Fabry patients
Noninvasive in vivo confocal microscopy (IVCM) detected signs of nerve damage in the cornea — the eye’s transparent outer layer — in people with Fabry disease, who also had higher levels of inflammatory immune cells in the cornea than…
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Qnity and SK hynix Sign Long-Term CMP Pad Supply Agreement
About Qnity
Qnity, DuPont’s Electronics business, is a premier technology solutions provider across the semiconductor value chain, empowering AI, high performance computing, and advanced connectivity. From groundbreaking solutions for semiconductor chip manufacturing, to enabling high-speed transmission within complex electronic systems, our high-performance materials and integration expertise make tomorrow’s technologies possible. More information about the company, its businesses and solutions can be found at www.qnityelectronics.com. Investors can access the initial Form 10 filing and amendments for Qnity on its investor website.Qnity™, the Qnity Node Logo, and all products, unless otherwise noted, denoted with ™ or ® are trademarks, trade names or registered trademarks of affiliates of Qnity Electronics, Inc.
About DuPont
DuPont (NYSE: DD) is a global innovation leader with technology-based materials and solutions that help transform industries and everyday life. Our employees apply diverse science and expertise to help customers advance their best ideas and deliver essential innovations in key markets, including electronics, transportation, construction, water, healthcare, and worker safety. More information about the company, its businesses, and solutions can be found at www.dupont.com. Investors can access information included on the Investor Relations section of the website at investors.dupont.com.DuPont™, the DuPont Oval Logo, and all trademarks and service marks denoted with ™, ℠ or ® are owned by affiliates of DuPont de Nemours, Inc. unless otherwise noted.
* On January 15, 2025, DuPont de Nemours, Inc. (“DuPont”) announced it is targeting November 1, 2025 to complete the intended separation of its Electronics business (the “Intended Electronics Separation”) by way of a spin-off transaction, thereby creating Qnity Electronics, Inc., a new independent, publicly traded electronics company. The Intended Electronics Separation will not require a shareholder vote and is subject to satisfaction of customary conditions, including final approval by DuPont’s Board of Directors, receipt of tax opinion from counsel, the completion and effectiveness of a Form 10 registration statement with the U.S. Securities and Exchange Commission, applicable regulatory approvals and satisfactory completion of financing.
Cautionary Statement Regarding Forward-Looking Statements
This release contains forward-looking statements. Forward-looking statements use words such as “plans”, “expects”, “will”, “would”, “anticipates”, “believes”, “intends”, “seeks”, “projects”, “efforts”, “estimates”, “potential”, “continue”, “intend”, “may”, “could”, “should” and similar expressions, among others, as well as other words or expressions referencing future events, conditions or circumstances. Statements that describe or relate to DuPont’s or Qnity’s plans, goals, intentions, strategies, DuPont’s or Qnity’s expectations regarding the Spin-Off, and statements that do not relate to historical or current fact, are examples of forward-looking statements. Forward-looking statements are based on our current beliefs, expectations and assumptions, which may not prove to be accurate, and involve a number of known and unknown risks and uncertainties, many of which are out of DuPont’s and Qnity’s control. Forward-looking statements are not guarantees of future performance, and there are a number of important factors that could cause actual outcomes and results to differ materially from the results contemplated by such forward-looking statements. Additional information concerning these and other factors can be found in DuPont’s and Qnity’s filings with the U.S. Securities and Exchange Commission, including DuPont’s most recent annual report on Form 10-K, most recent quarterly report on Form 10-Q and current reports on Form 8-K and Qnity’s registration statement on Form 10. Any forward-looking statement speaks only as of the date on which it is made. Neither DuPont nor Qnity undertake any obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by applicable law.
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